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KMID : 0381120110330010057
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Genes and Genomics
2011 Volume.33 No. 1 p.57 ~ p.63
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The polymorphisms of bovine PCSK1 gene and their associations with growth traits
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Shan Limin
Sun Jiajie
Zhang Chunlei
Fang Xingtang
Lei Chuzhao
Lan Xianyong
Chen Hong
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Abstract
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Proprotein convertase 1 (PCSK1) is an endopeptidase involved in proteolytic processing of peptide hormone precursors in granules of the regulated secretory pathway of endocrine cells and mutations in PCSK1 gene are thought to cause obesity. In the present study, based on PCR-SSCP and DNA sequencing methods, polymorphisms of the PCSK1 gene were detected in 858 individuals from five breeds (Nanyang cattle, Qinchuan cattle, Jiaxian cattle, Luxi cattle and Chinese Holstein). The results showed that only P8 locus showed polymorphisms and 3 synonymous SNPs of PCSK1 gene were identified. Additionally, significant statistical difference was found in bovine birth weight and diplotype MM were 7.35% higher than diplotype XY.
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KEYWORD
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Cattle, Growth traits, Mutation, PCSK1 gene, SSCP
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